Effects of EVOO consumption on vagus nerve activation

There is evidence that consuming extra virgin olive oil (EVOO) may indirectly influence vagus nerve activation, although not directly or exclusively.
Let’s start breaking it down…

What is the vagus nerve?
The vagus nerve is the main nerve of the parasympathetic nervous system. It is involved in regulating autonomic functions such as heart rate, digestion, inflammation, and emotional state.
Activating it can induce anti-inflammatory effects, improve mood, and promote intestinal health.

How does EVOO influence it?

1. Phenolic compounds and anti-inflammation:
   EVOO is rich in polyphenols (such as oleuropein, tyrosol, and hydroxytyrosol), which have anti-inflammatory effects.
   The vagus nerve is part of the so-called vagal inflammatory reflex, a mechanism that regulates inflammation. By reducing systemic inflammation, EVOO may indirectly promote vagus nerve modulation.
2. Effects on the gut-brain axis
   EVOO promotes a healthy gut microbiota, which is associated with improved vagus nerve signaling.
   A balanced microbiota can stimulate the production of metabolites (such as short-chain fatty acids) that activate the vagus nerve and improve gut-brain communication.
3. Improved lipid profile and cardiovascular function
   EVOO improves lipid profiles and reduces oxidative stress. A healthy cardiovascular system promotes better autonomic regulation, where the vagus nerve plays a central role.

What does the science say?
There are no direct studies that say “EVOO activates the vagus nerve,” but there are:
Studies linking EVOO-rich diets (such as the Mediterranean diet) with greater vagal tone (assessed by heart rate variability, HRV).
Evidence that EVOO improves biomarkers associated with functions regulated by the vagus nerve.

In short, we can affirm that EVOO is not a “direct activator” of the vagus nerve, but rather promotes physiological conditions that enhance or positively regulate it, especially through:

1. Reducing inflammation
2. Improving the gut microbiota
3. Optimizing the cardiovascular system